Affordable Kit For Cervical Cancer Detection.
Project Description :

The cervical cancer and cervical intra-epithelial neoplasia (cin) detection in india is mostly by means of a visual inspection with acetic acid which is considered much feasible and economical1 acetic acid is known to stain the cancerous cells in the cervix area by protein coagulation. via is quite economical and feasible when compared with the pap smear2. but still, this procedure hasn’t been effectively used and the most important problem being many of the women are not aware of the seriousness of the cervical cancer which is life threating and every year 80,000 women die only due to cervical cancer. we have made an attempt to quantify the visual inspection technique by means of reduction of chloroauric acid and would like to develop this into a kit which will be initially used as an assisted technique and would evolve as a personalized detection kit over future. in via, the process of detection is staining the cervix by acetic acid paste which would indicate abnormal white patches in case of cervical cancer. this isn’t quantitative and is confirmed by the naked-eye observation. the technique of quantification which we proposed involves the realization of the un-used acetic acid applied on the cervix. the acetic acid solution collected is used in the reduction of gold salt mediated by ascorbic acid. various percentages of acetic acid showed various colors indicating clearly the percent of acetic acid used up in the process of protein coagulation by cancerous cells, which will not only give an idea about presence of the cancer but also lets us quantify it visually and distinctly. the traditional via is mainly dependent on the naked eye observation of the aceto-white patches after application of acetic acid in the cervix region. if this qualitative method can be quantified by a simple reaction, the diagnostic results are expected to be more effective. the quantification technique can be easily embedded into a paper based device and could be used for diagnosis procedures without collection and storage of number of samples as in biopsy or pap smear. the detection kit would consist of a stiff paper based secluder and a strip/paper based device. the secluder to collect the fluid after applying 5% acetic acid. the sample so collected will be run on the strip/paper device which has one reservoir of ascorbic acid and other coated with gold salt for the intake of sample. the result could be visualized immediately without any further laboratory analysis. references: references: 1. rengaswamy sankaranarayanan, neerja bhatla, patti e. gravitt , partha basu, pulikattil o. esmy, k.s. ashrafunnessa, yasantha ariyaratne, aarati shah, bhagwan m. nene, vaccine, 26s (2008) m43–m52. 2. satyanarayana l, asthana s, bhambani s, sodhani p, gupta s, indian journal of cancer, june 2014, volume 51, issue 2.

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Project Details :
  • Date : Dec 13,2016
  • Innovator : Appidi Tejaswini
  • Team Members : Anurag Meena,Syed Basseruddin Alvi,Prof.Rohit Srivastava
  • Guide Name : Dr. Aravind Kumar Rengan, Dr. Rohit Srivastava
  • University : Indian Institutes of Technology Hyderabad
  • Submission Year : 2017
  • Category : Nano Science and Engineering
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